Death is something we wouldn’t ever wish on anyone, and if we had it our way, we want that our favorite celebrities could live forever. But the harsh truth is that death comes to all. Celebrities are public figures whom we idolize for the different emotions they invoke in us while they portray different characters on the big screen. Some stars’ passing shocked us because we could never have imagined that they dealt with secret medical issues of their own. Let’s take a look at 45 known names who said farewell to us too soon.

Dolores O’Riordan – Depression

Bipolar disorder can be life-changing, and life-threatening, too. If The Cranberries frontwoman Dolores O’Riordan had lived to this day, she would’ve had the same opinion. The 46-year-old Irish rock star, who split up with her partner for 20 years, Don Burton, in 2014, was recently found dead at Hilton London, an upscale hotel in London. Although the actual cause of her death is still ‘unexplained,’ her friends and near ones suspect that she was going through one of her occasional bouts of manic depression, which ultimately led to her rather untimely and sudden demise. It’s widely believed that the singer, who formed a new band called D.A.R.K. only recently, died of an accidental medication overdose.

2. Jeff Conaway – DRUG OVERDOSE

Jeff’s destiny might have been acting, considering that both his mom and dad were in the industry. Conaway became a star after appearing first on Grease, one of the most successful musicals of all time, and then in the comedy series, Taxi. He also had a recurring role in the TV show, Babylon 5. He developed a substance abuse problem, which he tried to overcome a number of times by going to rehab. He even made his struggle public by attending Celebrity Rehab With Dr. Drew. However, he always relapsed, falling back to using drugs and alcohol. His addiction killed him in 2011.

3. Chris Penn – HEART DISEASE

Chris Penn. who was known for movies like Reservoir Dogs and Pale Rider, was Sean Penn’s younger brother. Penn was often given roles about a pretty tough person or a totally comedic one. His talent was recognized and he won an award as Best Supporting Actor at the Venice Film Festival for his great performance on The Funeral.  But when Chris turned 40 years old, he developed a heart condition called “nonspecific cardiomyopathy.” He died eventually in January 2006, but his doctors said that medication might have been a contributing factor to his death.

4. James Avery – COMPLICATIONS FROM OPEN HEART SURGERY

You may recognize James Avery for he played the role of Uncle Phil on the show, The Fresh Prince Of Bel-Air. James had many other talents, including writing and a love for poetry. This might have been what led him to have the honor of giving not one but two commencement speeches at his alma mater in UC San Diego. When he was 68 years old, James had to undergo open-heart surgery. Some things were just really inevitable for his surgery had some complications that later led to his death in December 2013.

236. Michelle Thomas – RARE FORM OF CANCER

Family Matters fans will recognize Michelle Thomas for she played the role of Myra Monkhouse, the girlfriend of Jaleel White’s character, Steve Urkel. She first rose to stardom though, with her role in The Cosby Show, where she portrayed Justine Phillips. She later suffered from a rare type of carcinoma in the stomach called Intra-abdominal Desmoplastic Small-Round-Cell Tumor. Thomas underwent more than one surgery to remove the tumor, the last one in October 1998. She passed away in December 1998 and requested in her last testament that Muslim Tenets be carried out for her burial.